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Publications
New Ms: CaMKII activation in Barth syndrome
Liu, X. et al., Circulation in press
Barth syndrome cardiomyocytes from human iPSCs and mice have abnormal calcium handling that is partially due to activation of CaMKII. Barth syndrome mice had increased vulnerability to arrhythmia, perhaps reflecting the abnormal calcium handling.
Publications
Sarcomeres regulate cardiomyocyte maturation through MRTF-SRF signaling
Sarcomere assembly promotes MRTF-SRF signaling to drive a feed-forward circuit that stimulates cardiomyocyte maturation.
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CAT-D opening
CAT-D opening is scheduled for 9/10/20.
Publications
New Ms: AAV Gene therapy for Barth Syndrome
Wang, S et al., Circ. Res. in press.
AAV gene therapy improved survival and heart and skeletal muscle function in a new mouse model of Barth syndrome.
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Ms accepted — Cardiomyocyte Maturation: New Phase in Development
in press in Circulation Research.
Cardiomyocyte maturation is the process whereby proliferative and glycolytic fetal cardiomyocytes become specialized to forcefully and efficiently contract billions of times in an animal’s lifespan. This review article by Yuxuan Guo and William Pu summarizes our current understanding of mechanisms that promote and coordinate the process of cardiomyocyte maturation.